Spacer bar
CRUK Homepage Molecular Enzymology
London Research Institute
-Clare Hall Laboratories-
-Cancer Research UK-
Charity Registration No. 1089464 -Terms and Conditions-

- Home - Introduction - Projects - People - Publications - Vacancies -

Spacer bar
mRNA Capping Enzyme

The structure of the mRNA capping enzyme from Paramecium bursaria Chlorella virus 1 (PBCV-1) have been solved both in complex with and reacted with GTP. Coordinates and diffraction data have been deposited with the Protein Data Bank from which copies are available. The accession numbers are 1CKM, 1CKN and 1CKO.

CAP Structure

Structure of Chlorella virus mRNA capping enzyme (open conformation), showing domain 1 in green, domain 2 in red and compexed GTP in blue.

A) Capping chemistry
B) Sequence and conserved motifs
C) Structure of mRNA capping enzyme
D) Binding of cap analogue
E) Reaction mechanism
F) Authors and references
Spacer bar

Web pages maintained by Robert Court